Table of Contents
Outlines: Part I
Outlines: Part II
What is a Macromolecule?
Protein Structures
Stochastic Nature of Polymer Dynamics
Stochastic Nature of Single Molecules
Fluctuation Measurements by Fluorescence Spectroscopy
From Discrete Markov Model to Continuous Diffusion
Brownian Motion (Diffusion) in a Continuous Energy Landscape
Quantitative Equation of Motion
Smoluchowski Equation, Markov Process & Chemical Kinetics
Single-Molecule Measurement and Fluctuation Analysis
Protein-Ligand Separation with AFM
Energy Landscapes in Forced Protein
-Ligand Separation
Hysteresis in Macromolecular Mechanics
Stochastic Forced Separation
From Muscle to Actin & Myosin
Internal & External of a Motor Protein
Equation for Motor Protein Movement
Limit of Rapid Biochemical Cycling
Potential of Averaged Force
Isometric Forces
Isotonic Movement
Entropy and Heat Dissipation
Heat Dissipation Rate
Positive Entropy Production Rate
Time-Reversibility and Equilibrium
Free Energy Landscape of Motor Proteins: the “Power Stroke” and the “Ratchet”
How motor proteins generate force?
Globular Protein Folding Energy Function and Force
Equation for Polyglobular Protein
Equilibrium Elasticity of A Chain
Force, Energy, and Work
Elasticity of Polyglobular Proteins
Macroscopic Elasticity
Nonlinear Diffusion Equations?
Summary
Summary (Continued)
Equations for Macromolecular Mechanics
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Author: Hong Qian
Email: qian@amath.washington.edu
Home Page: http://www.amath.washington.edu/~qian
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